Special lecture by Prof. Aaron Ciechanover, a nobel prize laureate in Chemistry (2004)
Posted on October 8, 2012
Invitation to the special lecture by Prof. Aaron Ciechanover; a Nobel prize laureate in chemistry 2004, on Thursday, 18th October 2012 at 5.00 – 6.00 PM, Meeting Room SI 213-214, Faculty of Science Building.
Prof. Aaron Ciechanover was born in Haifa, Israel in 1947. He is a Distinguished Professor in the Technion – Israel Institute of Technology in Haifa. He received his M.Sc. (1971) and M.D. (1975) from the Hebrew University in Jerusalem, and his D.Sc. (1982) from the Technion. There, as a graduate student with Dr. Avram Hershko and in collaboration with Dr. Irwin A. Rose from the Fox Chase Cancer Center in Philadelphia, USA, they discovered that covalent attachment of ubiquitin to a target protein signals it for degradation. They deciphered the mechanism of conjugation, described the general proteolytic functions of the system, and proposed a model according to which this modification serves as a recognition signal for a specific downstream protease. As a post-doctoral fellow with Dr. Harvey Lodish at the M.I.T., he continued his studies on the ubiquitin system and made additional important discoveries. It is now clear that ubiquitin-mediated proteolysis plays major roles in numerous cellular processes, and aberrations in the system underlie the pathogenesis of many diseases, among them certain malignancies and neurodegenerative disorders. Consequently, the system has become an important platform for drug development.
Honors & Awards:
1996-present: Member, Council of the European Molecular Biology Organization
1997: Henry Taub Prize (Technion, Israel) for Excellence in Research
1999: Wachter Prize, by the University of Innsbruck, Austria (with A. Hershko)
2000: The Albert Lasker Award in Basic Medical Research
2004: Nobel Prize in Chemistry (shared with Hershko and Rose)